Has anyone experience of Pseudomonas Aeruginosa??

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lugreen's picture
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Hello, further to my earlier post about Megan and her possible UTI; things did not get better and we had been too and fro from the Vets the last couple of weeks with various issues.  We finally got some baterical swabs sent for testing and the result that has come back is that she showed signs of UTI and Vaginitis and that these are now further complicated by Pseudomonas Aeruginosa.  I've done some reading and where I've found mention of it in bitches where it is linked to a UTI and Vaginitis the prospects do not seem good.  It's highly resistent to antibiotics and it seems that if you don't get rid of it you are playing a waiting game until it eventually wins the fight...  The antibiotics are not supposed to be given to a dog as young as Megs, but she is well in herself and the vet has advised we try; which we will do tonight if the blood test on her kidneys is ok.  I just wondered if anyone had any experience of this??

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Hi I haven't any experience or have I ever heard of this malady. But just read this link below. WOW that is a bad bacteria. And did you read it can infect humans too?
My heart goes out you both!!!  I would call this breeder and let him/her know about it. He probably needs to not breed anymore. It s in the dirt...ect...

http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa

Antibiotics that have activity against P. aeruginosa include:

    * aminoglycosides (gentamicin, amikacin, tobramycin);
    * quinolones (ciprofloxacin, levofloxacin, and moxifloxacin)
    * cephalosporins (ceftazidime, cefepime, cefoperazone, cefpirome, but not cefuroxime, ceftriaxone, cefotaxime)
    * antipseudomonal penicillins: ureidopenicillins and carboxypenicillins (piperacillin, ticarcillin: P. aeruginosa is intrinsically resistant to all other penicillins)
    * carbapenems (meropenem, imipenem, doripenem, but not ertapenem)
    * polymyxins (polymyxin B and colistin)[28]
    * monobactams (aztreonam)

These antibiotics must all be given by injection, with the exception of fluoroquinolones and of aerosolized tobramycin. For this reason, in some hospitals, fluoroquinolone use is severely restricted in order to avoid the development of resistant strains of P. aeruginosa. In the rare occasions where infection is superficial and limited (for example, ear infections or nail infections), topical gentamicin or colistin may be used.

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Just so you know Intercell AG is working on a vaccine. It's in in Phase II. of the study. The study is conducted in nine countries Europe and South America.

good luck and I'd let your vet know about this study.

lugreen's picture
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Hi Judy and Izzy,  thank you as ever for the info/advice!  I had seen the wiki page (and funnily enough work for the pharma company that owns gentamicin!) but not the Intercall AG study.  Will mention it to the vet later.  On the plus side, Megs is full of beans and i think that we've got a pretty good chance of the antibiotics working as we've caught it relatively quickly... fingers crossed for the blood test!

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Awesome LuGreen awesome..me too I worked in the hospital, home health, nursing home,..yadda yadda... so medical problems always perk up my ears LOL Good luck I pray she will be fine!

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Well the blood tests came back ok, no kidney damage - such good news!  :)

Megs is on Gentimicin injections (may have to see if i can get them from work!) for the next 10 days and then we will retest.  Fingers crossed this works.

Now we just have to argue our case with insurance company...  ::)

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Oh awesome awesome! Always have to argue with insurance Co people or dogs!

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So 4 days in and poor Megs has bad diarrhoea, pain at the injection sites and signs of disorientation.  She's on a probiotic too and the vet is hoping to keep her going for 7 days of injections instead of 10 and then carry out another test.   We, meanwhile, are running out of ways to make rice exciting (thank God for OXO cubes) and are up at 2am every night because she can't last the night without a toilet break... at least we're no longer moving house next week! that really would be too much  :o

She’s a fighter though and is developing some very cheeky habits; especially ones that involve stealing my daughter’s teddy bears!   

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The disorientation awww that concerns me!! But does happen with some human patients. They usually change the meds. but she probably stay on it! Poor baby! Sending hugs!!

Thanks for keeping us updated!!

Izzy is going for ear cropping today! another poor baby!!!

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Thanks Judy - and best of luck to Izzy, I'm really keen to see how she looks when it's all done.  Cropped ears are a rarity here!

And (as you can see :)) I love your pitapata ticker - really useful too, I'm forever counting on fingers when people ask me how old Megs is now  ::)

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awww that is a cute ticker. Love it!!! And lol I got the ticker for the same reason...I was always getting her weeks wrong!!

Thanks! I am going to take a few before and after pictures in a bit!!

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The vets was horrible this evening!  Megs had the blood taken first and was fine (mummy not so!) but when it came to the injection she was instantly unhappy.  The injection stings and the site where she's having them is obviously now very sore.  It took three of us to pin her down, the first needle bent and I ended up with my jaw in her mouth for a few, very interesting seconds!  Luckily she was as surprised as me and there was no intent to bite at all so I have just some indents and probably a bruise.  But we will not be doing any more injections, they are taking too much out of her and the vet doesn't want her to become so scared of needles that she's impossible in the future.  So bloods ok today, fingers crossed for the swab test tomorrow... otherwise it's back to the drawing board.

rgreen4's picture
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My heart goes out to you and Megan. I hope she begins to feel better. I will keep you and her in my prayers.

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Dang a bent needle?...hmmmm Well.....keep up undated!

lugreen's picture
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Thank you both - done swab test done and waiting for the results...

Meanwhile she is obviously happier in herself, much calmer than she's been of late and we're all sleeping through the night again  :)

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I had planned yesterday, until my laptop decided to play up and now doesn't like the internet  >:(, to post with the very good news that Meg's latest swab is free of pseudomonas.  She does, however, have e coli but the vet said that with the probiotics and a little more rest it should clear and we'd spare her any more nasty drugs. 

We noticed that the Science Plan she was on was going straight through her and so had changed it to Wainwrights hypoallergenic mixed in with rice and chicken (she's looking thin bless her, we need to do something to build her back up).  It seemed to be working, still soft, but less times a day and starting to look more normal.

Until this afternoon, the dog walker spent an hour cleaning up Megs and the crate after what she described as "the most horrible" diaorrhea (and she's not a woman who exaggerates!) and she says that Megs is very lethargic again and now also drooling  ???  I am at a loss at to what we can do to get her well.  We only seem to manage a couple of days between bouts of illness or treatment and then we seem to have another issue crop up.  I know that these things take time, but in the 7 1/2 weeks that we have had her, she has been ill for 6 of them and I think that a combination of lack of sleep and worry (plus moving house etc etc) warps your perception of time a little!  It feels like this has been going on for years... and I don't want her to be unwell all the time.  She gives you that wonderful, noble but slightly sad, dobe look that they do so well and i just want to be able to make it all better  :(

Sorry folks, just getting it off my chest!  Anyways, i guess these should go in general, but here's my latest pics of (not so) little one - they're cheerier than i am!  :)

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Oh! awwwe my heart goes out to you both!! Hugs to Megs and Mommy!!! Meg she is such a sweet looking girl! She is lucky, no BLESSED  to have you as her Mom!!

I too have had a time with lots of poops, to diarrhea, to soft. I probably should just put Izzy back on Purina Pro puppy since she was doing so well on it when I got her. What was Megs eating do you think maybe it was the change? I added white rice to Izzy and she is OK but still needs to be a bit firmer to me.

Have an easy and warm day!

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Oh and .... I love both pictures, but the last one is soooo Doberman ahahahha love it!

Lady Kate's picture
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Pet Profiles

Lucy, I am just so sorry you're going through so much with Missy Megs. She is such an adorable puppy and I know that stoic "I'm not going to complain, but I feel Gawd-awful" look.
Six weeks of sick pup is enough to really try your patience not to mention the lack of rest. I know you must be almost frantic by now. Could she possibly be getting into anything toxic on her walks? Any insecticide or mold retardent  in the new place? ( I say new, but 1372 is kinda old especially compared to the states..)Her resistance must be at an all time low. Has the vets been giving her IV's for dehydration?
Prayers and best thoughts going to you!
Kate and Sofia

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I rushed home from work (via the dogwalker's with a large thank you bottle of wine!) to find, thankfully, no repeats of earlier but my darling girl is manic! (currently eating a wellington boot) and the last hour has been a comedy of errors!

I put her out in the garden while I finished cleaning up the house.  Just as I thought I was finished, I could smell poo (Indy had let Megs into the house) and as I am frantically looking for the source Indy and Megs are doing what 9 yr olds and puppies do  :)  I found the poo, with a paw print in it... the sofa covers, Indys rug and bedding and the bath mat are all now waiting their turn in the washing machine!  Never mind the carpet in the hallway and stairs!  I got that all sorted.. Megs is now eating and then vomiting up (all over the chicken run) my ornamental grass... I clean up the chooks, move all the pot plants and replant the ornamental grass (the guinea pigs hutch looks very pretty with them all piled on its roof!)... Megs in back in the living room and now eating the seat pads of the sofa we've just sold  ;D ;D ;D

Then the OH walks in, from the pub, full of tales of woe because his dad, aunt and uncles have been telling him how cruel crate training is - never mind that their dogs ate the kitchen, conservatory etc etc!  I know where I'd rather have been but it restored my sense of humour  ;D

Megs then demolished her dinner of rice (I should have shares in rice Judy!) and kibble and chicken; i debated the kibble but decided she needs the nutrients.  And now OH is walking Megs and I am enjoying the peace and quiet and a glass of wine.

Kate, I think you're right about the toxic "whatever it is" - that's why I've removed all the plants and I've told OH to keep her away from the stream on the walk.  Sadly, we're not in the new house yet (end of June if we're lucky) and there is nothing here to be worried about; though I did find a chewed up washing up sponge in the garden this pm  ???  Her immune system must be wreaked, so we'll just have to be extra vigilant for now and keep up with the probiotics etc.

Hugs to Izzy and Sofia  :)

and PS, if this post seems a little random its because it's my third attempt... the laptop is as sick as Megs it seems!!!

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Pet Profiles

Geez.. what a nightmare. Hope everyone wakes up soon
The poor little girl is probably so hungry yet nothing will agree with her.. Rice is good with some Chicken broth ( not the canned.. it has too much sodium,  boil your own chickens ( oh oh.. did I read chicken run?/ Does that mean you have chickens?) Look out chickies.. here comes Megan's Momma!!
I read comic relief in your story.. I do that too. If you can't laugh.. well.. you gotta admit eating sold sofa pads IS funny.
Thinking about you and hoping for better news tomorrow
cheers

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Lugreen - my heart goes out to you a and Megan. I will disagree with your OH on the crates. I not only confines them, it actually protects them as well. Canines by nature like dens. When I had some of my Dobies in an outside pen, they dug under the storage building I had inside the pen (70' x 100') rather than stay in the dog houses provided. (I don't think they ever went in either of them).

Both of mine are in crates as have all my previous Dobies for the last 18 years. It reduces the damage that they can do when I am not here and when I am otherwise occupied around the house. The only thing they can eat is their crate pad (which Red and Princess have both done recently).

There was a episode recently of diarrhea with Princess that I could not understand, as she had also vomited the night before and there were strands of what looked like extra long grass in it, but it was brown and dry, not green and fresh. I later discovered all the filler in the base of an artifical plant in the corner of the living room was missing. Yep, she had been eating it. No telling what kind of flame retardant chemicals she had gotten into. It obviously did not agree with her.

Unfortunately with dogs, almost anything strange will go into their mouth. A couple of weeks ago a large moth had come into the house with the dogs, and before I could get to it, she had swallowed it. Normally, dogs have a cast iron stomach, but that is as adults.

I also traditionally keep the door to my bedroom closed. This reduces the opportunities for Princess to get to my socks. She seems to have a thing for getting my socks and chewing them up. Thankfully she has never gone after my shoes. Red also likes to get them, but he doesn't chew them up, he just carries them around. His trick as a puppy was to chew the ends off my shoe laces. I now as a habit tuck them into the shoes when I take them off.

As to the diarrhea, I keep Imodium pills on hand. On checking with my vet, it is ok to give a Dobie Imodium. But for relief over the next few days is where the chicken and rice comes in. It is nourishing and easy to digest. As for the chicken broth, you can get it with low sodium and no MSG, although it may be harder to find. It is what I buy because of MSG intolerance. (I am not alergic, just very bad heart burn from it). The 14oz can has 570mg of sodium, but you probably wouldn't use the entire can at one time.

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Hi RGreen, thanks for the Immodium tip.  We have some so I will keep them on hand!

OH and I agree with you completely on crates, it's his family that don't.  But they all have great memories of dogs that ate this, chased that, couldn't be trusted with other dogs/people/children/animals etc. and think that it's perfectly normal.  They see Megs and say what a good girl she is but I guess think that it is down to genetics and has nothing to do with how we raise her.  And funnily enough, his sister's lab puppy who has free rein of the house and no boundaries or rules etc. has destroyed wallpaper and a carpet and her conservatory!  it is a Marley & Me lab  ;D

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Maybe you should show her some of the discussion threads on this forum. Let her know that all puppies are by nature uncontrollable and destructive, it's the training that makes the difference.

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lugreen wrote:
and PS, if this post seems a little random its because it's my third attempt... the laptop is as sick as Megs it seems!!!

Hey girl I just had to clean the insides of my laptop as it was running too hot and and shutting it's self down.
This is what it could look like....however these are not mine just samples. But it still was dusty enough to over heat!

If it is a virus you can get a free one I have used for years!!
http://www.avast.com/free-antivirus-download

This is a free scanner online....you can use to check for a virus.
http://housecall.trendmicro.com/

Hope this helps!

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Oh dear Judy, I did laugh! that is one unhappy machine!  ;D

I have a dear dear friend who, in return for a plate of food, will spend a nano-second doing what it's taken me hours not to  ??? and so laptop is now all better!

Megs on the other hand is showing symptoms of vaginitis again (we need a grrr smiley!) but no UTI (yet!) and keeping food down better.  We had a long chat in the car back from our weekend away (while we were still relaxed and thinking better!) and decided that if our vets initial recommendation would be probiotics we'd get our own (not at vet prices) and treat it homeopathically for a couple of weeks.  Cue one very confused guy at the healthfood shop who nevertheless got his head round the "I have a 6mth doberman" question and came up with a combination of pre and probiotics and antioxidents to add to the cranberry she already takes  ;D  Megs thinks they're all treats and wolfs them down.  We'll know soon enough if we're not succeeding and in the meantime, it can only be doing her good.

Also read up on Nzyme products - they look very very good - no UK stockists tho it seems, so back to google to see if they'll ship international.

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PS meant to say, Judy, have you thought of something similar for Izzy (ie cranberry etc.) and look up Nzyme, they do a solution that you can use to wipe her clean, stops the irritation and also if she ingests it seemingly continues to help clear up the infection, unlike topical creams.  We were always recommended to put Canestan on Megs, but the vet couldn't confirm it wouldn't do her any harm if she licked it off (which she would!) so we have resisted so far.  Would definately try the Nzyme solution if I could get my hands on it!

http://www.nzymes.com/pc/viewPrd.asp?idproduct=48  it's the Ox-E Drops and Antioxident granules that I saw recommended.

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lugreen wrote:

Oh dear Judy, I did laugh! that is one unhappy machine!  ;D I have a dear dear friend who, in return for a plate of food, will spend a nano-second doing what it's taken me hours not to  ??? and so laptop is now all better!

Yea!!! Glad you got some help!!! It is always good to have a geek for pet!  ;D

Quote:

Megs on the other hand is showing symptoms of vaginitis again (we need a grrr smiley!) but no UTI (yet!) and keeping food down better. 

Also read up on Nzyme products - they look very very good - no UK stockists tho it seems, so back to google to see if they'll ship international.

LOL at the confused guy... Hmmm? never heard of that brand here in the states....so I looked it up found this post but not a vet

RE: Dog with Yeast Infection on Skin and in Throat
"My little girl suffers from yeast. I found medicated baths such as nizoral shampoo, apple cider vinegar 1/2 and equal amounts of water and canesten cream works well."

and I found this link below in the UK....so it looks like they do use it on animals. What about putting the it on, then put a diaper on her and keep her close so she wont tear it off...well just my thoughts...

http://www.petmedsfromvets.co.uk/medication.php?p=show_drug_prescription...
and wow I might get some of this when I can

What to Look For in an Enzyme Supplement
The four enzymes commonly found in food, and therefore, used in enzyme supplements are: amylase (digests starches), cellulase (breaks down fibrous foods), lipase (splits large fats into fatty acids), and protease (acts on protein). There are also many other enzymes, such as glucoamylase, sucrase, lactase, alpha-galactosidase, phytase and peptidase, to name a few, that ensure further digestion of all food groups. When selecting an enzyme supplement to recommend to a patient, be certain at least the four primary types are present to assure digestion of the main food components. The presence of other enzymes only improves the digestive effectiveness of the supplement.

Animal enzymes (pancreatin) and plant enzymes (bromelain and papain) concentrate their digestive activity on breaking down protein.  However, vegetarian enzymes from safe, mycological sources provide a full spectrum of enzymes for more complete digestion.

Digestive Enzymes and Systemic Enzymes
In addition to adding an enzyme supplement to assist with digestion, taking enzyme supplements between meals has proven helpful in other areas including: reducing inflammation, boosting immune function, maintaining cardiovascular health, maximizing endocrine effectiveness, detoxification, and promoting normal respiratory function.

lugreen wrote:

PS meant to say, Judy, have you thought of something similar for Izzy (ie cranberry etc.) and look up Nzyme, they do a solution that you can use to wipe her clean, stops the irritation and also if she ingests it seemingly continues to help clear up the infection, unlike topical creams.  We were always recommended to put Canestan on Megs, but the vet couldn't confirm it wouldn't do her any harm if she licked it off (which she would!) so we have resisted so far.  Would definately try the Nzyme solution if I could get my hands on it!

http://www.nzymes.com/pc/viewPrd.asp?idproduct=48  it's the Ox-E Drops and Antioxident granules that I saw recommended.

I did as you suggested last time and have Izzy on crannberry and probotics pills!!! Along with her antibotics. I am going to mortrow to get a big jusg of plain yogurt from Walmart. Do you all have a Walmart?

Here is more info on that...Maybe you can find something as good by another brand.
http://www.enzymesinc.com/supplemental-information/enzyme-supplements-he...

I am ab it confused with all the links I found I hope I haven't repeated any and that they help!!